Cytochrome P450 Epoxygenase CYP2J2 and the Risk of Coronary Artery Disease

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• 作者：Martin Spiecker and JamesK. Liao
• 刊名：Trends in Cardiovascular Medicine
• 出版年：2006
• 出版时间：August 2006
• 年：2006
• 卷：16
• 期：6
• 页码：204-208
• 全文大小：102 K

文摘

Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolizes arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11,12-epoxyeicosatrienoic acid, has several vasoprotective effects. A frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease. This association supports the vascular protective role of CYP-derived eicosanoids in cardiovascular disease.