Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra
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- 作者：Pablo Garcia-Reitboeck ; Oleg Anichtchik ; Jeffrey W. Dalley ; Natalia Ninkina ; George K. Tofaris ; Vladimir L. Buchman ; Maria Grazia Spillantini
- 关键词：¦Á-Synuclein ; Dopaminergic ; Embryonic development ; Parkinson's disease ; Transgenic mouse
- 刊名：Experimental Neurology
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：248
- 期：Complete
- 页码：541-545
- 全文大小：517 K
文摘
The presynaptic protein ¦Á-synuclein is central to the pathogenesis of ¦Á-synucleinopathies. We show that the presence of endogenous mouse ¦Á-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deletion of the ¦Á-synuclein gene or C57Bl/6J mice with a targeted deletion of the ¦Á-synuclein gene. This effect of ¦Á-synuclein on dopaminergic neuron occurs during development between E10.5 and E13.5 and persists in adult life supporting the involvement of ¦Á-synuclein in the development of a subset of dopaminergic neurons.