Urinary 3-hydroxypropyl mercapturic acid (3-HPMA) concentrations in dogs with acute spinal cord injury due to intervertebral disc herniation

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• 作者：A.M. Sangster^a ; ^b ; L. Zheng^b ; R.T. Bentley^a ; R. Shi^b ; ^c ; ^{riyi@purdue.edu} ; R.A. Packer^a ; ^b
• 关键词：Acrolein ; 3-Hydroxypropyl mercapturic acid ; Canine acute spinal cord injury ; Intervertebral disc herniation ; Lipid peroxidation
• 刊名：The Veterinary Journal
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：219
• 期：Complete
• 页码：12-14
• 全文大小：309 K
• 卷排序：219

文摘

Urinary 3-hydroxypropyl mercapturic acid (3-HPMA) is a metabolite of acrolein. In dogs with intervertebral disc herniation, urinary 3-HPMA concentrations were higher than in control dogs. Urinary 3-HPMA concentrations were not correlated with the severity of canine acute spinal cord injury (ASCI). Urinary 3-HPMA concentrations of intact dogs were higher than that of neutered dogs. 3-HPMA is a potential biomarker in canine acute spinal cord injury (ASCI).