Spinosad induces programmed cell death involves mitochondrial dysfunction and cytochrome C release in Spodoptera frugiperda Sf9 cells

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• 作者：Mingjun Yang^a ; Bo Wang^a ; Jufang Gao^b ; Yang Zhang^a ; Wenping Xu^a ; Liming Tao^a ; ^{taolm@ecust.edu.cn}
• 关键词：Spinosad ; Programmed cell death ; Mitochondrial dysfunction ; Cytochrome C release
• 刊名：Chemosphere
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：169
• 期：Complete
• 页码：155-161
• 全文大小：1188 K
• 卷排序：169

文摘

Spinosad exhibited toxicological effect on Sf9 cells. Spinosad induced significant mitochondrial dysfunction in Sf9 cells. Spinosad induced cytochrome C release was partly due to the mPTP opening. Spinosad induced mitochondria-dependent programmed cell death in Sf9 cells.