The insecticide spinosad induces DNA damage and apoptosis in HEK293 and HepG2 cells

详细信息    查看全文

• 作者：Mingjun Yang ; Guanggang Xiang ; Diqiu Li ; Yang Zhang ; Wenping Xu ; Liming Tao ; ^{taolm@ecust.edu.cn}
• 关键词：Spinosad ; DNA damage ; Comet assay ; H2AX foci ; Apoptosis ; Cytotoxic
• 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：812
• 期：Complete
• 页码：12-19
• 全文大小：1841 K
• 卷排序：812

文摘

This study evaluates the cytotoxicity of spinosad and its mode of action in HEK293 and HepG2 cells. Spinosad induced increases on single- and double-strand DNA breaks in HEK293 and HepG2 cells. DNA damage-induced p53 accumulation and modulation of Bcl-2/Bax ratio in HEK293 and HepG2 cells. Spinosad induced disruption of the mitochondrial membrane potential in HEK293 and HepG2 cells. Spinosad induced apoptosis in HEK293 and HepG2 cells through mitochondrial pathways.