Catalytic cycloalumination in steroid chemistry: The introduction of a spirotetrahydrofuran or spirotetrahydroselenophene moiety into a 3¡ä-methylene-(5¦Á)-spirocholestane-3,1¡ä-cyclobutane molecule

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• 作者：Vladimir A. D’ ; yakonov ; ^{DyakonovVA@rambler.ru} ; Regina A. Tuktarova ; Ilgiz I. Islamov ; Leonard M. Khalilov ; Usein M. Dzhemilev
• 关键词：Cycloalumination ; Zirconocene dichloride ; Dzhemilev reaction ; Aluminacyclopentane ; Spiranes ; Organoaluminum compounds
• 刊名：Steroids
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：78
• 期：2
• 页码：241-246
• 全文大小：277 K

文摘

Cycloalumination of 3¡ä-methylene-(5¦Á)-spirocholestane-3,1¡ä-cyclobutane with triethylaluminum catalyzed by Cp₂ZrCl₂ was accomplished for the first time to give (5¦Á)-spirocholestane-3,1¡ä-(6¡ä-ethyl-6¡ä-aluminaspiro [3.4] octane) in 89 % . The latter, without isolation, was converted into spirotetrahydroselenophene or spirotetrahydrofuran.