Biochemical characterization and zinc binding group (ZBGs) inhibition studies on the catalytic domain of MMP7 (cdMMP7)

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• 作者：Fan Meng ; Hao Yang ; Colin Jack ; Huaqun Zhang ; Abraham Moller ; Devin Spivey ; Richard C. Page ; ^{pagerc@miamioh.edu} ; David L. Tierney ; ^{tiernedl@miamioh.edu} ; Michael W. Crowder ; ^{crowdemw@miamioh.edu}
• 关键词：Matrix metalloproteinases (MMPs) ; Pre-steady-state kinetic study ; Cobalt(II)-substitution ; Zinc-binding group MMP inhibitors (ZBG-MMPis)
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：165
• 期：Complete
• 页码：7-17
• 全文大小：1223 K
• 卷排序：165

文摘

Optimization of method to refold catalytic domain of matrix metalloproteinase 7 (cdMMP7) Kinetic mechanism of cdMMP7 determined by stopped-flow pre-steady-state studies Preparation and characterization of a ZnCo heterobimetallic analog of cdMMP7 Assessment and characterization of zinc binding groups with cdMMP7