Molecular determinants of bacterial sensitivity and resistance to mammalian Group IIA phospholipase A2
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文摘

Humans express ten closely related secreted phospholipases A2(sPLA2).

Unique features of Group IIA sPLA2: strong cationicity; nM antibacterial activity.

Cationic properties of sPLA2-IIA promote bacterial binding, cell wall penetration.

Bacterial death follows membrane phospholipid degradation, activation of autolysins.

Antibacterial actions of sPLA2-IIA enhanced by other host defense systems.

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