The role of the gastrointestinal tract in the pathogenesis of rheumatic diseases
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- 作者：Francesco Ciccia ; francesco.ciccia@unipa.it ; Angelo Ferrante ; Giuliana Guggino ; Giovanni Triolo
- 关键词：Rheumatoid arthritis ; Spondyloarthropathy ; Connective tissue diseases ; Gastrointestinal tract ; Dysbiosis
- 刊名：Best Practice & Research Clinical Rheumatology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：30
- 期：5
- 页码：889-900
- 全文大小：1141 K
- 卷排序：30
文摘
Dysregulation of the intestinal epithelial barrier in genetically susceptible individuals may lead to both intestinal and extraintestinal autoimmune disorders. There is emerging literature on the role of microbiota changes in the pathogenesis of systemic rheumatic diseases such as rheumatoid arthritis, spondyloarthropathies, and connective tissue diseases. Although the role of the gastrointestinal tract in the pathogenesis of spondyloartropathies is well defined and many studies underline the importance of gastrointestinal inflammation in modulating local and systemic inflammation, the data are inconclusive regarding the effect of dysbiosis on rheumatoid arthritis and connective tissue diseases. This review aims to summarize current data on the role of the gastrointestinal involvement and intestinal microbiota in the pathogenesis of systemic rheumatic disease.