Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors
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- 作者：Litsa Nikitidou Ledria ; Esbjö ; rn Melina ; Sø ; ren H. Christiansenb ; Casper R. Gø ; tzscheb ; Alessandra Cifraa ; David P.D. Woldbyeb ; Mé ; rab Kokaiaa ; Merab.Kokaia@med.lu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Intrahippocampal kainate injection ; Spontaneous seizures ; Gene therapy ; Neuropeptides ; Adeno-associated viral vectors
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：52-61
- 全文大小：1905 K
文摘
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A translationally designed model of spontaneous seizures is characterized.
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NPY/Y2-overexpression in the hippocampus prevents progression of seizures.
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Chronic seizure frequency is abated by NPY/Y2-overexpression.
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Time spent in seizures is attenuated by NPY/Y2-overexpression.