Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats
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- 作者：Beatriz Oliveira Amorima ; 1 ; Clement Hamania ; b ; c ; Elenn Ferreiraa ; 1 ; Maí ; sa Ferreira Mirandad ; Maria José ; S. Fernandese ; Antonio M. Rodriguesd ; Antô ; nio-Carlos G. de Almeidad ; Luciene Covolana ; lucovolan@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARRIVE ; Animal Research ; Reporting of In Vivo Experiments ; CTL ; control ; DC ; direct current ; DPCPX ; 8-cyclopentyl-1 ; 3-dipropylxanthine ; Pilo ; pilocarpine ; PS ; population spikes ; RPia ; (R)-N-phenylisopropyladenosine ; SE ; status epilepticus ; SRS ; spontaneous recurrent seizures ; TLE ; temporal lobe epilepsy
- 刊名：Epilepsy & Behavior
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：168-173
- 全文大小：925 K
文摘
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Hypothesis 1: the A1 receptor agonist RPia decreases the frequency of SRS and hippocampal excitability in epileptic rats.
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Hypothesis 2: the A1 receptor antagonist DPCPX increases the frequency of SRS and hippocampal excitability in epileptic rats.
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RPia treatment resulted in 93% non-significant reduction in the frequency of seizures
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DPCPX resulted in 87% significant increase in seizure rate.
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One possible mechanism for seizure control relies on hippocampal excitability.