Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment
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- 作者：Josy Carolina C. Pontesa ; Thiago Z. Limab ; Claudio M. Queirozc ; Simone M. Cininia ; Miriam M. Blancoa ; Luiz E. Melloa ; lemello@unifesp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：AEDs ; antiepileptic drugs ; CBZ ; carbamazepine ; ECoG ; electrocorticogram ; LFP ; local field potential ; PB ; phenobarbital ; PFA ; paraformaldehyde ; PSD ; power spectrum density ; PTZ ; pentylenetetrazole ; SE ; status epilepticus ; SNr ; substantia nigra pars reticulate ; SRF ; serum response factor ; SRSs ; spontaneous recurrent seizures ; TLE ; temporal lobe epilepsy ; VPA ; valproic acid
- 刊名：Epilepsy Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：126
- 期：Complete
- 页码：16-25
- 全文大小：3229 K
文摘
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Marmosets with epileptic background are more susceptible to seizures induced by PTZ.
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PTZ-induced seizures were remarkably less attenuated by AEDs in epileptic marmosets.
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Epileptic marmosets with stronger seizures had greater expression of NPY and ΔfosB.
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This model has an improved translational value for the screening of new AEDs.