Initial subjective reward to alcohol in Sprague-Dawley rats

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• 作者：Todd B. Nentwig^a ; ^{tbn004@bucknell.edu} ; Kevin P. Myers^b ; Judith E. Grisel^b ; ^{j.grisel@bucknell.edu}
• 关键词：Conditioned place preference ; Alcohol use disorder ; Ethanol ; Sex differences ; Susceptibility ; Novelty
• 刊名：Alcohol
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：58
• 期：Complete
• 页码：19-22
• 全文大小：321 K
• 卷排序：58

文摘

Sprague-Dawley rats show place preference to a context paired once with ethanol. Male rats only prefer a context paired with drug on the first day of the procedure. Females prefer the drug-paired context independent of experimental day. Initial subjective rewarding effects of alcohol are readily demonstrated in rats. Our procedure offers researchers a tool to study the risk for alcohol use disorders.