刊名:International Journal of Radiation Oncology*Biology*Physics
出版年:2004
出版时间:February 1, 2004
年:2004
卷:58
期:2
页码:536-541
全文大小:290 K
文摘
Endostatin is a 20-kD C-terminal fragment of collagen XVIII and is a potent inhibitor of angiogenesis. Imaging technologies that use near-infrared (NIR) fluorescent probes are well suited to the laboratory setting. The goal of this study was to determine whether endostatin labeled with a NIR probe (Cy5.5) could be detected in an animal after intraperitoneal injection and whether it would selectively localize in a tumor.