In vivo tumor imaging using a near-infrared–labeled endostatin molecule
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- 作者：Citrin ; Deborah ; Scott ; Tamalee ; Sproull ; Mary ; Menard ; Cynthia ; Tofilon ; Philip J. ; Camphausen ; Kevin
- 关键词：Near-infrared ; Angiogenesis ; Endostatin ; Murine
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2004
- 出版时间：February 1, 2004
- 年：2004
- 卷：58
- 期：2
- 页码：536-541
- 全文大小：290 K
文摘
Endostatin is a 20-kD C-terminal fragment of collagen XVIII and is a potent inhibitor of angiogenesis. Imaging technologies that use near-infrared (NIR) fluorescent probes are well suited to the laboratory setting. The goal of this study was to determine whether endostatin labeled with a NIR probe (Cy5.5) could be detected in an animal after intraperitoneal injection and whether it would selectively localize in a tumor.