A cytokine axis regulates elastin formation and degradation

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• 作者：Erin P. Sproul ^{pardue@musc.edu} ; W. Scott Argraves ; ^{argraves@musc.edu}
• 关键词：TGF¦Â1 ; transforming growth factor ¦Â-1 ; EGFR ; epidermal growth factor receptor ; CAT ; chloramphenicol acetyl-transferase ; PKC ; protein kinase C ; MMP ; matrix metalloproteinase ; IGF-1 ; insulin-like growth factor-I ; Rb ; retinoblastoma protein ; bFGF ; basic fi
• 刊名：Matrix Biology
• 出版年：2013
• 出版时间：11 March, 2013
• 年：2013
• 卷：32
• 期：2
• 页码：86-94
• 全文大小：497 K

文摘

Underlying the dynamic regulation of tropoelastin expression and elastin formation in development and disease are transcriptional and post-transcriptional mechanisms that have been the focus of much research. Of particular importance is the cytokine-governed elastin regulatory axis in which the pro-elastogenic activities of transforming growth factor ¦Â-1 (TGF¦Â1) and insulin-like growth factor-I (IGF-I) are opposed by anti-elastogenic activities of basic fibroblast growth factor (bFGF/FGF-2), heparin-binding epidermal growth factor-like growth factor (HB-EGF), EGF, PDGF-BB, TGF¦Á, tumor necrosis factor-alpha (TNF-¦Á), interleukin (IL)-1¦Â and noncanonical TGF¦Â1 signaling. A key mechanistic feature of the regulatory axis is that cytokines influence elastin formation through effects on the cell cycle involving control of cyclin-cyclin dependent kinase complexes and activation of the Ras/MEK/ERK signaling pathway. In this article we provide an overview of the major cytokines/growth factors that modulate elastogenesis and describe the underlying molecular mechanisms for their action on elastin production.