Predictive Risk Factors for Failure to Induction Therapy of Lupus Nephritis in a Cohort of Colombian Patients

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• 作者：Luis Fernando Pinto Peñ ; aranda^a ; Inis Lizeth Castro Mercado^b ; Vladimir Duque Caballero^b ; Javier Darí ; o Má ; rquez Herná ; ndez^c ; Carlos Jaime Velá ; squez Franco^a ; ^b ; ^{carjaivel@hotmail.com" class="auth_mail} ; ^{carjaivel@gmail.com" class="auth_mail}
• 关键词：Lupus nephritis ; Remission induction ; Nephrotic syndrome
• 刊名：Reumatología Clínica (English Edition)
• 出版年：May-June 2014
• 年：2014
• 卷：10
• 期：3
• 页码：147-151
• 全文大小：433 K

文摘

To determine the predictors of failure to obtain remission after induction therapy for proliferative lupus nephritis in a group of northwestern Colombian patients.

Material and methods

A retrospective study was conducted. We included patients with systemic lupus erythematosus according to the American College of Rheumatology criteria who had nephritis confirmed by renal biopsy.

Results

We followed 84 patients: 88.1% female, and 11.9% male. The mean age at diagnosis of systemic lupus erythematosus was 27.5±11.8 years (9–70). The average time between diagnosis of systemic lupus erythematosus and proliferative nephritis onset was 13.6 months (0–168). Histopathologic type: IV (78.57%), III (15.47%), III–IV/V (5.96%). Activity index: 6.7±4.6. Chronicity index: 2±2.7. 24-hour proteinuria (mg): 6164 (130–18,100). Baseline creatinine: 1.14 mg/dL (0.43–7.4). Induction therapy: Steroids (100%), cyclophosphamide (76.2%) and mycophenolate mofetil (23.8%). At six months, 56% of individuals failed to achieve partial or complete remission. Predictors of failure to induction therapy were, in accordance with the bivariate analysis (OR; 95% CI): creatinine level more than 1.2 mg/dL (10.8; 3.18–36.84; P < .005), nephrotic range proteinuria (11.9; 3.09–45.8; P < .001), and an activity index above 8 (5.04; 1.7–14.3; P < .001). In the multivariate analysis, only baseline creatinine higher than 1.2 mg/dL (10.92; 2.65–45.02; P = .001), and nephrotic range proteinuria (9.81; 1.85–52.04; P = .007) were significant.

Conclusions

A significant percentage of Colombian patients fail to achieve remission of proliferative lupus nephritis after six months of treatment.