Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy

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• 作者：Vengadeshprabhu Karuppagounder ; Ph.D.^a ; Somasundaram Arumugam ; Ph.D.^a ; Vijayasree V. Giridharan ; Ph.D.^b ; Remya Sreedhar ; Ph.D.^a ; Rajendran J.C. Bose ; Ph.D.^c ; Jyothi Vanama ; Ph.D.^d ; Suresh S. Palaniyandi ; Ph.D.^e ; Tetsuya Konishi ; Ph.D.^a ; ^f ; Kenichi Watanabe ; M.D. ; Ph.D.^a ; Rajarajan A. Thandavarayan ; Ph.D.^g ; ^{Atrajarajan@gmail.com}
• 关键词：Diabetic cardiomyopathy ; Curcumin ; Diabetes mellitus ; Inflammation ; Bioavailability ; Oxidative stress ; Heart failure
• 刊名：Nutrition
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：34
• 期：Complete
• 页码：47-54
• 全文大小：1996 K
• 卷排序：34

文摘

Diabetic cardiomyopathy (DCM) is a major chronic complication of diabetes mellitus. Multiple signaling pathways may combine to produce pathological changes in DCM. Curcumin is a potent pleiotropic molecule that regulates multiple pathways. Pharmacokinetics of curcumin makes limited usage in clinical settings. Various approaches to improve curcumin pharmacokinetics are addressed.