Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series
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- 作者：Sreekanth Ramach ; ran ; Manoranjan P ; a ; Kakoli Mukherjee ; Nilanjana Roy Choudhury ; Subramanyam J. Tantry ; Chaitanya Kumar Kedari ; Vasanthi Ramach ; ran ; Sreevalli Sharma ; V.K. Ramya ; Supreeth Guptha ; Vasan K. Samb ; amurthy
- 关键词：Antimycobacterial activity ; Whole cell screening ; Structure activity relationship ; Physicochemical properties
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2013
- 出版时间：1 September, 2013
- 年：2013
- 卷：23
- 期：17
- 页码：4996-5001
- 全文大小：1887 K
文摘
Imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead were generated by whole cell screening of a focused library against Mycobacterium tuberculosis. Herein, we describe the synthesis and structure activity relationship evaluation of this class of inhibitors and the optimization of physicochemical properties. These are selective inhibitors of Mycobacterium tuberculosis with no activity on either gram positive or gram negative pathogens.