Elucidating the role of genomics in neonatal sepsis

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• 作者：Lakshmi Srinivasan ; MBBS^a ; ^{srinivasanl@email.chop.edu" class="auth_mail" title="E-mail the corresponding author} ; Haresh Kirpalani ; BM ; MSc^a ; Charles Michael Cotten ; MD ; MHS^b
• 关键词：sepsis ; genetics ; neonate ; gene association
• 刊名：Seminars in Perinatology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：39
• 期：8
• 页码：611-616
• 全文大小：392 K

文摘

Sepsis is a major cause of neonatal morbidity and mortality, especially in vulnerable preterm populations. Immature immune defenses, and environmental and maternal factors contribute to this risk, with as many as a third of very preterm infants experiencing sepsis during their stay in the neonatal intensive care unit (NICU). Epidemiologic and twin studies have suggested that there is a genetic contribution to sepsis predilection. Several investigators have conducted candidate gene association studies on variants of specific interest and potential functional significance in neonatal sepsis. In this review, we describe details of studies that have evaluated genetic susceptibility in neonatal sepsis, and summarize findings from a review of candidate gene association studies.