ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis
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- 作者：Ritesh K. Srivastavaa ; Changzhao Lia ; Aftab Ahmadb ; Onika Abramsc ; Marina S. Gorbatyukd ; Kevin S. Harrodb ; Ronald C. Weke ; Farrukh Afaqa ; Mohammad Athara ; mathar@uab.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; Arsenic ; ATF4 ; Ca++ release ; ER-mitochondria crosstalk
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：609
- 期：Complete
- 页码：39-50
- 全文大小：4351 K
文摘
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ATO-mediated NADPH oxidase complex formation and activation require ATF4.
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ATO-mediated dysregulation of Ca++ homeostasis is ATF4 dependent.
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ATO-mediated alterations in mitochondria are ATF4 dependent.
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ER-mitochondrial crosstalk in the toxicity of ATO is regulated by ATF4.