Preliminary study on the distribution of selected elements in cancerous and non-cancerous kidney tissues

详细信息    查看全文

• 作者：Wojciech M. Kwiatek ; Tomasz Drewniak ; Mariusz Gajda ; Marek Gał ; ka ; Albert L. Hanson ; Tadeusz Cichocki
• 关键词：trace elements ; kidney ; cancer ; synchrotron ; perfusion
• 刊名：Journal of Trace Elements in Medicine and Biology
• 出版年：2002
• 出版时间：2002
• 年：2002
• 卷：16
• 期：3
• 页码：155-160
• 全文大小：4039 K

文摘

In this study special interest was given to trace elements recognized as to be carcinogenic to humans. The kidney tissue sections were analyzed in order to determine the concentrations of elements present in the sample. The Synchrotron Radiation Induced X-ray Emission (SRIXE) technique was applied using a white photon microbeam. The results from cancerous parts of the kidney tissues were compared to non-cancerous parts and to the control group. In addition the iron concentration level was determined in the serum of those patients. Two-dimensional scans are presented to illustrate the differences between perfused and not-perfused tissues.

According to this study there is no significant difference in the Mn concentration between cancerous and non-cancerous parts of the kidney, but the concentrations of Cd, Cr, Ti, V, Cu, Se, and Zn are at a lower concentration level in the cancerous parts than in the non-cancerous parts. A converse observation has been made for Fe. This may be associated with different metabolism and dynamics of the cancer process and both higher vascularization and need of higher blood supply in the cancerous tissue. The two-dimensional scanning of thin kidney sections showed differences in the trace element distributions depending on the analyzed samples: perfused and non-perfused. Perfusion removed blood mostly from the peritubular capillaries while in the glomerulus some capillaries had a relatively high Fe content. A low Fe concentration was observed in nephron tubules while a converse observation has been made for Cd. This may indicate that Cd is localized in the cells but not in the blood.