Caspase-related apoptosis genes in gliomas by RNA-seq and bioinformatics analysis
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- 作者：Rui Wanga ; Bo Weic ; Jun Weib ; Zhaohui Lic ; Yu Tianc ; Chao Duc ; chaodu303@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; Caspase inhibitor ; Differentially expressed gene ; Enrichment analysis ; Gliomas ; Protein-protein interaction
- 刊名：Journal of Clinical Neuroscience
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：259-263
- 全文大小：561 K
文摘
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A set of 105 caspase inhibitor-related, apoptotic, differentially expressed genes in gliomas are selected.
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TUBB2A, RPSA, RPL5, PSMC3 and KHSRP are crucial genes for gliomas.
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These genes are highly associated with metabolism-related functions and pathways.
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PSMC3 and RPL5 were highlighted in the protein-protein interaction network.
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KHSRP and TUBB2A were predicted as targets of cefotaxime, cefacetrile and netilmicin.