Expression of miR-638 is reduced in lung cancer tissues.
Downregulation of miR-638 is related to the invasion and proliferation of lung cancer cell lines.
Direct binding of miR-638 to the SOX2 3′-UTR is confirmed.
miR-638 overexpression diminishes but miR-638 knockdown increases SOX2 expression levels in vitro.
Aberrant expression of miR-638 is related to invasion and proliferation of NSCLC by regulating SOX2.