Temporal control of glucocorticoid neurodynamics and its relevance for brain homeostasis, neuropathology and glucocorticoid-based therapeutics
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- 作者：Konstantinos Kalafatakisa ; kk13382@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author ; kgkalafatakis@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Georgina M. Russella ; georgina.russell@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Apostolos Zarrosb ; a.zarros@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Stafford L. Lightmana ; stafford.lightman@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glucocorticoid pulsatility ; Ultradian rhythmicity ; Glucocorticoid-based therapeutics ; Neuropsychopathology ; Glucocorticoid neurodynamics ; Mineralocorticoid receptors ; Glucocorticoid receptors
- 刊名：Neuroscience & Biobehavioral Reviews
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：12-25
- 全文大小：1886 K
文摘
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Glucocorticoids (GCs) have multi-level, sometimes conflicting effects in the brain.
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GCs achieve complex neurodynamics, guided by their circadian and ultradian rhythmicity.
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Ultradian rhythmicity leads to a spatial and temporal mosaic of GC-dependent actions in the brain.
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The temporal relationship between GC pulses and other (physiological, pathological) stimuli lead to different effects.
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GC rhythmicity needs to be taken into consideration for effective GC-based therapeutic strategies.