Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans
详细信息 查看全文
- 作者：Anna-Maria Ordelheide1 ; 2 ; Nadja Gommer3 ; Anja Bö ; hm1 ; 2 ; 3 ; Carina Hermann1 ; 2 ; Inga Thielker1 ; 2 ; Fausto Machicao1 ; 2 ; Andreas Fritsche1 ; 2 ; 3 ; 4 ; Norbert Stefan1 ; 2 ; 3 ; Hans-Ulrich Hä ; ring1 ; 2 ; 3 ; Harald Staiger1 ; 2 ; 3 ; harald.staiger@med.uni-tuebingen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Granulocyte colony-stimulating factor (G-CSF) ; Saturated fatty acid-induced myokine ; Fatty acid-induced insulin resistance
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：5
- 期：4
- 页码：305-316
- 全文大小：1407 K
文摘
- •
CSF3, the gene encoding G-CSF, is induced in human myotubes by saturated, but not unsaturated, FFAs.
- •
CSF3 expression is induced via Toll-like receptor 4-dependent and -independent pathways.
- •
Human adipocytes and myotubes treated with G-CSF become insulin-resistant.
- •
A CSF3 SNP affects insulin sensitivity and glucose tolerance in human subjects with elevated plasma FFA concentrations.
- •
G-CSF emerges as a new player in FFA-induced insulin resistance.