Association of MMP-2 and MMP-9 expression with recurrences in primary spontaneous pneumothorax

详细信息    查看全文

• 作者：Ying-Fong Huang^a ; Wen-Chin Chiu^b ; Shah-Hwa Chou^b ; Yu-Han Su^c ; Yu-Wen Chen^a ; Chee-Yin Chai^d ; Chih-Jen Huang^e ; Ming-Yii Huang^e ; Shyng-Shiou F. Yuan^c ; ^f ; Yi-Chen Lee^g ; ^{yichen83@kmu.edu.tw}
• 关键词：Matrix metalloproteinase ; Pneumothorax ; Recurrence ; Type II pneumocyte
• 刊名：The Kaohsiung Journal of Medical Sciences
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：1
• 页码：17-23
• 全文大小：841 K
• 卷排序：33

文摘

Primary spontaneous pneumothorax (PSP) is a common benign problem. However, PSP recurrence is still a troublesome complication for most patients. This study intended to determine the role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in type II pneumocytes of patients with PSP and its relation with recurrence. Ninety-one patients who had undergone needlescopic video-assisted thoracoscopic surgery wedge resection of lung with identifiable blebs for PSP were included in this study. Immunohistochemical (IHC) staining was used to measure the expression of MMP-2 and MMP-9 in lung tissues of PSP patients. The results were further correlated with clinicopathological parameters and recurrence rates using chi-square or Fisher's exact test. The value of MMP-2 and MMP-9 for overall recurrence was analyzed by univariate and multivariable Cox regression model. IHC data revealed that MMP-2 and MMP-9 staining was predominantly observed in type II pneumocytes of patients with PSP. We found that MMP-2 and MMP-9 expression in PSP, especially male PSP patients, was significantly correlated with recurrence. In the univariate and multivariate analyses, MMP-2 and MMP-9 were statistically significant risk factors for overall recurrence in PSP patients. Therefore, high expression levels of MMP-2 and MMP-9 in type II pneumocytes show a positive correlation with PSP recurrence risk. Further studies are needed to validate whether reduction of MMP-2 and MMP-9 expression may be a promising way for decreasing the risk of PSP recurrence in the future.