Problem: Nitric oxide (NO) is considered to prevent local infections in paranasal sinus. As sphenoidal sinusitis is rare our hypothesis was that NO concentration is higher in spenoidal sinus than in maxillary sinus. The sphenoidal sinus is not easily accessible and NO concentration in this sinus has been reported in one patient. We studied the presence of NO and NO-synthesizing enzymes (NOS), in the maxillary and sphenoidal sinus.