Substituted 2,6-bis(benzimidazol-2-yl)pyridines: A novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase
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- 作者：Simone Musiua ; Gerhard Pü ; rstingerb ; Sylvia Stallingerb ; Robert Vranckenc ; 1 ; Andy Haegemanc ; Frank Koenenc ; Pieter Leyssena ; Mathy Froeyena ; Johan Neytsa ; Johan.Neyts@rega.kuleuven.be" class="auth_mail ; Jan Paeshuysea
- 关键词：Bovine viral diarrhea virus ; RNA-dependent RNA polymerase ; Substituted 2 ; 6-bis(benzimidazol-2-yl)pyridine inhibitors
- 刊名：Antiviral Research
- 出版年：June 2014
- 年：2014
- 卷：106
- 期：Complete
- 页码：71-79
- 全文大小：1014 K
文摘
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BBP is a selective inhibitor of BVDV and CSFV replication.
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Resistant viruses carry mutation I261M for BVDV or I261N/P262A for CSFV in the RdRp.
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BBP-resistant pestiviruses show cross-resistant to known pestivirus inhibitors.
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Inactive in an in vitro BVDV RdRp assay.
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BBP does inhibit the activity of BVDV replication complexes.