文摘
Sulforaphane inhibited osteoclast differentiation and osteoclast cell-fusion. Sulforaphane suppressed not only NFATc1, but also cell-cell fusion molecules, DC-STAMP and OC-STAMP. Sulforaphane decreased multinucleated osteoclasts, whereas increased mono-nucleated osteoclasts. Sulforaphane inhibits the cell-cell fusion by inducing the phosphorylation of STAT1 (Tyr701).