Synthesis of optically active (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octan-2-one

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• 作者：Nikolay T. Tzvetkov ; Philip Schmoldt ; Beate Neumann ; Hans-Georg Stammler and Jochen Mattay
• 刊名：Tetrahedron: Asymmetry
• 出版年：2006
• 出版时间：20 March 2006
• 年：2006
• 卷：17
• 期：6
• 页码：993-998
• 全文大小：192 K

文摘

Bicyclo[2.2.2]octanone is an important building block for the synthesis of bioactive compounds and natural products. Herein, we present a new synthetic route for the formation of (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octan-2-one derivatives via a catalytic asymmetric Michael reaction in high stereoselectivity and yields.