Tirucallane triterpenoids from the stem bark of Araliopsis synopsis

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• 作者：Emmanuel Ngeufa Happi ; Alain Tadjong Tcho ; Jovita Chi Sirri ; Jean Duplex Wansi ; Beate Neumann ; Hans-Georg Stammler ; Jean W ; ji ; Norbert Sewald
• 关键词：Araliopsis synopsis ; Rutaceae ; Tirucallane triterpenoids ; Antimicrobial and Cytotoxic activities
• 刊名：Phytochemistry Letters
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：5
• 期：3
• 页码：423-426
• 全文大小：235 K

文摘

Two new tirucallane triterpenoids, 21-methoxy-21,23-epoxy-tirucalla-7,24-dien-3¦Á-ol (1) and 21-methoxy-21,23-epoxy-tirucalla-7,24-diene-1¦Á,3¦Á-diol (2), together with thirteen known compounds were isolated from the CH₂Cl₂ extract of the stem bark of Araliopsis synopsis. The structures of the compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral (EI and ESI) data and comparison with previously known analogs. Compounds 1-10 were tested against bacteria, fungi and plant pathogen oomycetes by the paper disk agar diffusion assay resulting in missing to low activities corresponding with MICs > 1 mg/mL. However, compounds 5-10 exhibited high cytotoxic activity against the human Caucasian prostate adenocarcinoma cell PC-3 line, with IC₅₀ 8.5-12.5 ¦ÌM compared to the standard Doxorubicin with IC₅₀ = 0.9 ¦ÌM, while compounds 1, 3 and 4 showed low activity.