Microsecond Dissection of Neurotransmitter Release: SNARE-Complex Assembly Dictates Speed and Ca2+ Sensitivity
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- 作者：Claudio Acuna1 ; claudioa@stanford.edu" class="auth_mail ; Qingchen Guo2 ; Jacqueline Burré ; 1 ; Manu Sharma1 ; Jianyuan Sun2 ; 3 ; Thomas C. Sü ; dhof1 ; tcs1@stanford.edu" class="auth_mail
- 刊名：Neuron
- 出版年：4 June 2014
- 年：2014
- 卷：82
- 期：5
- 页码：1088-1100
- 全文大小：2269 K
文摘
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Constitutively opening syntaxin-1 accelerates SNARE-complex assembly
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Opening syntaxin-1 increases the apparent Ca2+ affinity of release ∼2-fold
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Constitutively opening syntaxin-1 accelerates release in calyx-of-Held synapses
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Opening syntaxin-1 accelerates fusion-pore opening rates of individual vesicles