The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins

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• 作者：Helena Gylling ; Maarit Hallikainen ; Markku J. Nissinen ; Tatu A. Miettinen
• 关键词：Plant stanol ester ; LDL cholesterol ; Carotenoids ; α ; -Tocopherol ; Vitamin D ; Liver enzymes
• 刊名：Clinical Nutrition
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：29
• 期：1
• 页码：112-118
• 全文大小：231 K

文摘

Summary

Background & aims

Intake of 2–3 g/d of plant stanols as esters lowers LDL cholesterol level, but there is no information about the efficacy and safety of a respective very high daily intake. We studied the effects of 8.8 g/d of plant stanols as esters on serum lipids and safety variables in subjects with mild to moderate hypercholesterolemia.

Methods

In a randomized, double-blind, placebo-controlled study the intervention (n = 25) and control (n = 24) groups consumed spread and drink enriched or not with plant stanol esters for 10 weeks.

Results

Plant stanols reduced serum total and LDL cholesterol concentrations by 12.8 and 17.3 % from baseline and by 12.0 and 17.1 % from controls (P < 0.01 for all). Liver enzymes, markers of hemolysis, and blood cells were unchanged. Serum vitamins A, D, and γ-tocopherol concentrations, and the ratios of α-tocopherol to cholesterol were unchanged. Serum β-carotene concentrations decreased significantly from baseline and were different from controls even when adjusted for cholesterol. Serum α-carotene concentration and α-carotene/cholesterol ratio were not different from controls.

Conclusions

High intake of plant stanols reduced LDL cholesterol values without any other side effects than reduction of serum β-carotene concentration. However, the end product, serum vitamin A levels, were unchanged. The results suggest that plant stanol ester intake can be increased to induce a greater cholesterol lowering effect.