A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: Results of a meta-analysis of randomized, placebo-controlled trials

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• 作者：Kathy Musa-Veloso ; ^a ; ^{kmusa-veloso@cantox.com"" rel=""nofollow} ; Theresa H. Poon^a ; Julie Ann Elliot^a ; Catherine Chung^a
• 关键词：Plant stanols ; Plant sterols ; Phytostanols ; Phytosterols ; Plant stanol ester ; Plant sterol ester ; LDL-cholesterol ; Dose-response ; Meta-analysis
• 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
• 出版年：2011
• 出版时间：July 2011
• 年：2011
• 卷：85
• 期：1
• 页码：9-28
• 全文大小：447 K

文摘

Purpose

To determine if plant stanols and plant sterols differ with respect to their low-density lipoprotein cholesterol (LDL-CH) lowering efficacies across a continuous dose range.

Methods

Dose-response relationships were evaluated separately for plant stanols and plant sterols and reductions in LDL-CH, using a first-order elimination function.

Results

Altogether, 113 publications and 1 unpublished study report (representing 182 strata) complied with the pre-defined inclusion and exclusion criteria and were included in the assessment. The maximal LDL-CH reductions for plant stanols (16.4 % ) and plant stanol ester (17.1 % ) were significantly greater than the maximal LDL-CH reductions for plant sterols (8.3 % ) and plant sterol ester (8.4 % ). These findings persisted in several additional analyses.

Discussion and conclusions

Intakes of plant stanols in excess of the recommended 2 g/day dose are associated with additional and dose-dependent reductions in LDL-CH, possibly resulting in further reductions in the risk of coronary heart disease (CHD).