A novel cathelicidin from Bufo bufo gargarizans Cantor showed specific activity to its habitat bacteria
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- 作者：Tongyi Suna ; Bo Zhana ; Yuanyuan Gaob ; yyg20062006@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：A. hydrophila ; Aeromorus hydrophila ; A. loloensis ; Amolops loloensis ; AMPs ; Antimicrobial peptides ; B. bufo gargarizans Cantor ; Bufo bufo gargarizans Cantor ; CD ; Circular dichroism ; CFU ; Colony-Forming Units ; E. coli ; Escherichia coli ; L. bacterium ; Lysogenic bacterium ; MIC ; minimal inhibitory concentration ; P. aeruginosa ; Pseudomonas aeruginosa ; S. aureus ; Staphylococcus aureus ; S. iniae ; Streptococcus iniae ; T. verrucosus ; Tylototriton verrucosus ; V. harveyi ; Vibrio harveyi ; V. splendidus ; Vib
- 刊名：Gene
- 出版年：2015
- 出版时间：25 October 2015
- 年：2015
- 卷：571
- 期：2
- 页码：172-177
- 全文大小：1132 K
文摘
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cDNA encoding cathelicidin termed BG-CATH was identified.
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Two peptides were synthesized and their biological activities were investigated.
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Strong antibacterial activities against V. splendidus, S. iniae and A. hydrophila
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Unlike other AMPs or cathelicidins, they adopted random-coil conformations.
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Evolutionary analysis suggests cathelicidins might evolve from two ancestors.