Secrets of the secretome in Staphylococcus aureus

详细信息    查看全文

• 作者：Harald Kusch ; Susanne Engelmann
• 关键词：Secretome ; Protein secretion ; Hypothetical proteins ; Proteomics ; Staphylococcus aureus
• 刊名：International Journal of Medical Microbiology
• 出版年：March, 2014
• 年：2014
• 卷：304
• 期：2
• 页码：133-141
• 全文大小：1383 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Summary

Secreted proteins constitute a reservoir of virulence factors. Here, an in silico analysis of the secretome of 15 S. aureus reference strains is presented revealing that about 30% of the encoded proteome of this bacterium could be secreted. In total 1354 proteins were predicted to be localized outside the cytoplasm representing the pan-secretome of S. aureus. 41% of these proteins have been identified to be expressed using different approaches. The function of at least 50% of the secreted proteins encoded by S. aureus is not yet clear and a possible role in virulence has to be elucidated.