Immunologic effects of continuous-flow left ventricular assist devices before and after heart transplant

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• 作者：Byung-Soo Ko ; MD^a ; ^d ; Stavros Drakos ; MD ; PhD^a ; ^b ; ^d ; Abdallah G. Kfoury ; MD^c ; ^d ; Denise Hurst ; MS^e ; Gregory J. Stoddard ; MPH^f ; Carrie A. Willis ; MD^c ; ^d ; Julio C. Delgado ; MD ; MS^e ; Elizabeth H. Hammond ; MD^e ; ^g ; Edward M. Gilbert ; MD^a ; ^b ; ^d ; Rami Alharethi ; MD^c ; ^d ; Monica P. Revelo ; MD ; PhD^e ; Jose Nativi-Nicolau ; MD^a ; ^b ; ^d ; Bruce B. Reid ; MD^h ; Stephen H. McKellar ; MD ; MSⁱ ; Omar Wever-Pinzon ; MD^a ; ^b ; ^d ; Dylan V. Miller ; MD^g ; David D. Eckels ; MD^e ; James C. Fang ; MD^a ; ^b ; ^d ; Craig H. Selzman ; MDⁱ ; Josef Stehlik ; MD ; MPH^a ; ^b ; ^d ; ; for the Utah Transplant Affiliated Hospitals (U.T.A.H.) Cardiac Transplant Program
• 关键词：continuous-flow left ventricular assist device ; allosensitization ; transplant outcome ; acute cellular rejection ; antibody-mediated rejection
• 刊名：Journal of Heart and Lung Transplantation
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：35
• 期：8
• 页码：1024-1030
• 全文大小：887 K

文摘

Immune allosensitization can be triggered by continuous-flow left ventricular assist devices (CF LVAD). However, the effect of this type of allosensitization on post-transplant outcomes remains controversial. This study examined the post-transplant course in a contemporary cohort of patients undergoing transplantation with and without LVAD bridging.

Methods

We included consecutive patients who were considered for cardiac transplant from 2006 to 2015. Serum alloantibodies were detected with single-antigen beads on the Luminex platform (One Lambda Inc., Canoga Park, CA). Allosensitization was defined as calculated panel reactive antibody (cPRA) > 10%. cPRA was determined at multiple times. LVAD-associated allosensitization was defined as development of cPRA > 10% in patients with cPRA ≤ 10% before LVAD implantation. Post-transplant outcomes of interest were acute cellular rejection (ACR), antibody-mediated rejection (AMR), and survival.

Results

Allosensitization status was evaluated in 268 patients (20% female). Mean age was 52 ± 12 years, and 132 (49.3%) received CF LVADs. After LVAD implant, 30 patients (23%) became newly sensitized, and the level of sensitization appeared to diminish in many of these patients while awaiting transplant. During the study period, 225 of 268 patients underwent transplant, and 43 did not. A CF LVAD was used to bridge 50% of the transplant recipients. Compared with patients without new sensitization or those already sensitized at baseline, the patients with LVAD-associated sensitization had a higher risk of ACR (p = 0.049) and higher risk of AMR (p = 0.018) but a similar intermediate-term post-transplant survival. The patients who did not receive a transplant had higher level of allosensitization, with a baseline cPRA of 20% vs 6% in those who received an allograft and a high risk (40%) of death during follow-up.

Conclusions

New allosensitization takes place in > 20% of patents supported with CF LVADs. Among patients who undergo transplant, this results in a higher risk of ACR and AMR, but survival remains favorable, likely due to the efficacy of current management after transplant. However, mortality in sensitized patients who do not reach transplant remains high, and new approaches are necessary to meet the needs of this group of patients.