文摘
Nitration of 1-aryl(or 1-benzyl)pyrroles 1, 2 and 7 has provided the corresponding 2- and 3-nitropyrroles3 and 5, 4 and 6, and 8 and 9 in a 1:2 ratio. Reductive cyclisation of 3 and 8, gave pyrrolo[1,2-a]quinazolines 11 and 12, and pyrrolo[1,2-b][2,4]benzodiazepine 13, respectively. A conformational study of 5 in the solid and liquid state using X-ray diffraction analysis, molecular dynamics calculations and NMR spectroscopy, is described.