Liquid fiducial marker performance during radiotherapy of locally advanced non small cell lung cancer

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• 作者：Jonas Scherman Rydhö ; g^a ; ^b ; ^{jonas.scherman.rydhoeg@regionh.dk" class="auth_mail" title="E-mail the corresponding author} ; Steen Riisgaard Mortensen^a ; Klaus Richter Larsen^c ; Paul Clementsen^d ; ^e ; Rasmus Irming J&oslash ; lck^f ; ^g ; Mirjana Josipovic^a ; ^b ; Marianne Camille Aznar^a ; ^b ; Lena Specht^a ; Thomas Lars Andresen^f ; Per Munck af Rosenschö ; ld^a ; ^b ; Gitte Fredberg Persson^a
• 关键词：Image-guided radiotherapy ; Marker visibility ; Liquid fiducial marker ; NSCLC
• 刊名：Radiotherapy and Oncology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：121
• 期：1
• 页码：64-69
• 全文大小：553 K

文摘

We analysed the positional and structural stability of a long-term biodegradable liquid fiducial marker (BioXmark) for radiotherapy in patients with locally advanced lung cancer.

<h4 id="absSec_2">Material and methodsh4>

Markers were injected via endoscopic- or endobronchial ultrasound in lymph nodes and reachable primary tumours. Marker volume and Hounsfield Units (HU) changing rates were estimated using breath-hold CBCT. Inter-fraction variation in marker position relative to gross tumour volume (GTV) position was established, as well as the inter-fraction variation in mediastinal marker registration relative to a carina registration through the treatment.

<h4 id="absSec_3">Resultsh4>

Fifteen patients were included and 29 markers analysed. All markers that were in situ at planning were visible through the treatment. Mean HU was 902 ± 165 HU for lymph node and 991 ± 219 HU for tumour markers. Volume degradation rates were −5% in lymph nodes and −23% in primary tumours. Three-dimensional inter-fraction variation for marker position relative to the GTV position was −0.1 ± 0.7 mm in lymph nodes and −1.5 ± 2.3 mm in primary tumours. Inter-fraction variations in marker registration relative to carina registration were −0.4 ± 1.2 mm in left&ndash;right, 0.2 ± 2.0 mm in anterior&ndash;posterior and −0.5 ± 2.0 mm in cranio-caudal directions.

<h4 id="absSec_4">Conclusionsh4>

The liquid fiducial markers were visible and stable in size and position throughout the treatment course.