Dendronized mesoporous silica nanoparticles provide an internal endosomal escape mechanism for successful cytosolic drug release
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- 作者：Veronika Weissa ; 1 ; Christian Argyoa ; 1 ; Adriano A. Torranoa ; Claudia Strobelb ; Stephan A. Mackowiaka ; Alexandra Schmidta ; Stefan Datza ; Tim Gatzenmeiera ; Ingrid Hilgerb ; Christoph Brä ; uchlea ; christoph.braeuchle@cup.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Thomas Beina ; bein@lmu.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mesoporous silica nanoparticles ; PAMAM dendrimers ; Endosomal escape ; Drug nanocarriers ; Specific drug release
- 刊名：Microporous and Mesoporous Materials
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：227
- 期：Complete
- 页码：242-251
- 全文大小：1789 K
文摘
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Dendronized mesoporous silica nanoparticles for intracellular drug delivery.
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Low cytotoxicity with no impact on the metabolism of endothelial cells.
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Specific cancer cell targeting due to receptor-mediated cell uptake.
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Redox-driven cleavage of disulfide bridges allows stimuli-responsive cargo release.
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Endosomal escape based on the high buffering capacity of PAMAM dendrons.