Treatment of Wound Healing Disorders of Radial Forearm Free Flap Donor Sites Using Cold Atmospheric Plasma: A Proof of Concept

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• 作者：Stefan Hartwig ; MD ; DMD^&lowast ; ; ^{stefan.hartwig@charite.de} ; Christian Doll ; MD ; DMD^&lowast ; ; Jan Oliver Voss ; MD^&lowast ; ; Moritz Hertel ; DMD^&dagger ; ; Saskia Preissner ; DMD ; PhD^&Dagger ; ; Jan Dirk Raguse ; MD ; DMD ; PhD^§ ;
• 刊名：Journal of Oral and Maxillofacial Surgery
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：75
• 期：2
• 页码：429-435
• 全文大小：2156 K
• 卷排序：75

文摘

The treatment of wound healing disturbances of the radial forearm free flap donor site after reconstructive surgery is typically long and burdensome and often requires additional surgery. Cold atmospheric plasma is a promising approach to overcome these impairments. The aim of this proof of concept study was to evaluate the clinical outcome of plasma irradiation in patients with wound healing disorders with exposed brachial tendons of the radial forearm.Patients and MethodsFour patients (mean age 64.2 years, range 44 to 80) who had undergone radial forearm free flap procedures and developed wound healing disturbance leading to exposed flexor tendons were included in the present prospective case series. In addition to routine wound care, all sites were irradiated with cold atmospheric plasma. The primary outcome variable was complete wound closure.ResultsIn all patients, complete wound repair in terms of the absence of tendon exposure was observed within a mean treatment time of 10.1 weeks (range 4.9 to 16). No undesirable side effects were observed, and no inflammation or infection occurred.ConclusionsCold atmospheric plasma could offer a reliable conservative treatment option for complicated wound healing disturbances. This was exemplarily shown in the case of radial forearm free flap donor site morbidity with exposed flexor tendons in the present study.