Neutrophil NET formation is regulated from the inside by myeloperoxidase-processed reactive oxygen species
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- 作者：Halla Bjö ; rnsdottira ; Amanda Welina ; Erik Michaë ; lssonb ; Veronica Oslaa ; Stefan Bergc ; Karin Christensona ; Martina Sundqvista ; Claes Dahlgrena ; Anna Karlssona ; Johan Bylunda ; d ; johan.bylund@gu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：CGD ; chronic granulomatous disease ; CL ; chemiluminescence ; DAG ; sn-1 ; 2-dioctanoylglycerol ; DPI ; diphenyleneiodonium ; HRP ; horseradish peroxidase ; KRG ; Krebs-Ringer phosphate buffer ; MPO ; myeloperoxidase ; NETs ; neutrophil extracellular traps ; PEG ; polyethylene-glycol ; PHPA ; p-hydroxyphenylaceticacid ; PMA ; phorbol myristate acetate ; PKC ; protein kinase C ; ROS ; reactive oxygen species ; RT ; room temperature ; SOD ; superoxide dismutase
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：1024-1035
- 全文大小：7140 K
文摘
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PMA stimulation of human neutrophils induces ROS production in intracellular granules
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Intragranular ROS are processed by MPO after fusion of specific and azurophil granules
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MPO-processed intragranular ROS are necessary for PMA-triggered NET formation