Manganese ions enhance mitochondrial H2O2 emission from Krebs cycle oxidoreductases by inducing permeability transition
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- 作者：Erik Bonkea ; Ilka Siebelsa ; Klaus Zwickerb ; Stefan Drö ; sea ; Stefan.Droese@kgu.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ant ; antimycin A ; Atpn ; atpenin A5 ; CRC ; calcium retention capacity ; CsA ; cyclosporine A ; DQA ; 2-n-decyl-quinazolin-4-yl-amine ; FAD ; flavin adenine dinucleotide ; FCCP ; carbonyl-cyanide-p-trifluoro-methoxy-phenylhydrazone ; FMN ; flavin mononucleotide ; HRP ; horseradish peroxidase ; IMM ; inner mitochondrial membrane ; IMS ; intermembrane space ; 3-methyl-2-oxopentanoate ; (KMV ; α-keto-methylvalerate) ; MCU ; mitochondrial calcium uniporter ; mPT(P) ; mitochondrial permeability transition (pore) ; Myx ; myxothi
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：43-53
- 全文大小：5353 K
文摘
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We analyzed the effect of manganese on the H2O2 emission of rat heart mitochondria.
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Mn2+ increased the H2O2 emission by mitochondrial permeability transition (mPT).
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mPT favored H2O2 production from Kreb's cycle oxidoreductases.
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In addition, Mn2+ induced H2O2 production at the Q-site of complex II.