A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

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• 作者：James R. White ; Gareth J. Price ; Stefanie Schiffers ; Paul R. Raithby ; Pawel K. Plucinski ; Christopher G. Frost
• 刊名：Tetrahedron Letters
• 出版年：2010
• 出版时间：28 July 2010
• 年：2010
• 卷：51
• 期：30
• 页码：3913-3917
• 全文大小：1167 K

文摘

The stable benzylazido-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide–alkyne cycloaddition and Suzuki coupling reactions.