Induction chemotherapy followed by radiotherapy for larynx preservation in advanced laryngeal and hypopharyngeal cancer: Outcome prediction after one cycle induction chemotherapy by a score based on clinical evaluation, computed tomography-based volumetry and ¹⁸F-FDG-PET/CT

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• 作者：Gunnar Wichmann^a ; ¹ ; ^{gunnar.wichmann@medizin.uni-leipzig.de} ; ; Anne Kr&uuml ; ger^a ; ¹ ; Andreas Boehm^a ; Marlen Kolb^a ; Mathias Hofer^a ; Milos Fischer^a ; Stefan M&uuml ; ller^a ; Sandra Purz^b ; Patrick Stumpp^c ; Osama Sabri^b ; Andreas Dietz^a ; ² ; Regine Kluge^b ; ²
• 关键词：Head and neck cancer ; Laryngeal cancer ; Hypopharyngeal cancer ; Larynx preservation ; HNSCC ; Induction chemotherapy ; Early response evaluation ; 18F-FDG ; PET/CT ; Decision-making
• 刊名：European Journal of Cancer
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：144-155
• 全文大小：1760 K
• 卷排序：72

文摘

Larynx preservation (LP) in advanced larynx/hypopharynx squamous cell carcinoma (LHSCC) features uncertainties. After 1 cycle induction chemotherapy (IC-1) endoscopic response assessment of tumour surface shrinkage (ETSS) is recommended. This is the largest study in advanced LHSCC comparing ETSS, CT-volumetry and PET/CT after IC-1 in a prospective LP trial. Hazard ratios of 4 independent predictors define a new score for laryngectomy-free survival (LFS), the LFS-score. Responders with ETSS ≥ 30% and LFS-score ≤16 achieve prolonged LFS, tumour-specific and overall survival.