An efficient approximate moment method for multi-dimensional population balance models - Application to virus replication in multi-cellular systems

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• 作者：Robert D&uuml ; rr^a ; ^{robert.duerr@ovgu.de} ; Thomas M&uuml ; ller^a ; Stefanie Duvigneau^a ; Achim Kienle^a ; ^b
• 关键词：Multi-dimensional population balance modeling ; Direct quadrature method of moments ; Monomial cubature formulas ; Cell-to-cell variability ; Influenza virus replication ; Vaccine production
• 刊名：Chemical Engineering Science
• 出版年：2017
• 出版时间：16 March 2017
• 年：2017
• 卷：160
• 期：Complete
• 页码：321-334
• 全文大小：2387 K
• 卷排序：160

文摘

Approximate moment method to solve multidimensional population balance equations. Combination of the DQMOM with a sophisticated choice of weights and abscissas. Evaluation of the proposed technique for a five dimensional population balance model. Moments are accurately approximated while keeping the numerical effort moderate. Application to influenza A virus replication in mammalian cell cultures. Model based investigation of effects of genetic modifications on process.