- 作者：Mireen Friedrich-Rust ; Nina Schlueter ; Christina Smaczny ; Olaf Eickmeier ; Martin Rosewich ; Kirstin Feifel ; Eva Herrmann ; Thierry Poynard ; Wolfgang Gleiber ; Christoph Lais ; Stefan Zielen ; Thomas O.F. Wagner ; Stefan Zeuzem ; Joerg Bojunga
- 关键词：ARFI ; Liver stiffness ; CF ; Mucoviscidosis ; Cirrhosis
- 刊名：Journal of Cystic Fibrosis
- 出版年：2013
- 出版时间：September, 2013
- 年：2013
- 卷：12
- 期：5
- 页码：431-439
- 全文大小：511 K
Background
Patients with cystic fibrosis (CF) have a relevant morbidity and mortality caused by CF-related liver-disease. While transient elastography (TE) is an established elastography method in hepatology centers, Acoustic-Radiation-Force-Impulse (ARFI)-Imaging is a novel ultrasound-based elastography method which is integrated in a conventional ultrasound-system. The aim of the present study was to evaluate the prevalence of liver-fibrosis in patients with CF using TE, ARFI-imaging and fibrosis blood tests.Methods
106 patients with CF were prospectively included in the present study and received ARFI-imaging of the left and right liver-lobe, ARFI of the pancreas TE of the liver and laboratory evaluation.
Results
The prevalence of liver-fibrosis according to recently published best practice guidelines for CFLD was 22.6 % . Prevalence of significant liver-fibrosis assessed by TE, ARFI-right-liver-lobe, ARFI-left-liver-lobe, Fibrotest, Fibrotest-corrected-by-haptoglobin was 17 % , 24 % , 40 % , 7 % , and 16 % , respectively. The best agreement was found for TE, ARFI-right-liver-lobe and Fibrotest-corrected-by-haptoglobin. Patients with pancreatic-insufficiency had significantly lower pancreas-ARFI-values as compared to patients without.
Conclusions
ARFI-imaging and TE seem to be promising non-invasive methods for detection of liver-fibrosis in patients with CF.