Effect of antenatal betamethasone on maternal and fetal amino acid concentration

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• 作者：Anna Maria Marconi ; Valentina Mariotti ; Cecilia Teng ; Stefania Ronzoni ; Barbara D'Amato ; Alberto Morabito ; Frederick C. Battaglia
• 关键词：antenatal betamethasone ; amino acids ; human pregnancy
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：202
• 期：2
• 页码：166.e1-166.e6
• 全文大小：500 K

文摘

Objective

To determine the concentration of amino acids in women receiving the first course of antenatal betamethasone and to evaluate the umbilical venous and arterial amino acid concentrations at the time of elective cesarean section after betamethasone administration.

Study Design

Blood samples were collected from 34 pregnant women at risk of premature delivery before and 24 and 48 hours after the first course of betamethasone. In addition, maternal and cord blood samples were collected in 13 women undergoing an elective cesarean section between 24 and 192 hours after betamethasone.

Results

Maternal amino acid concentrations were significantly increased after the first dose of betamethasone. Overall total amino nitrogen increased 17.5 % 24 hours after betamethasone administration and 20.5 % after 48 hours. The concentration of most amino acids was increased both in the umbilical vein and artery after maternal betamethasone administration.

Conclusion

The concentration of maternal and fetal amino acids increases significantly after betamethasone administration.