Population genetic evaluation of 12 X-chromosomal short tandem repeats of Investigator Argus X-12 kit in North-East Italy

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• 作者：Stefania  ; Turrina  ; ;   ; ^{stefania.turrina@univr.it} ; Giulia  ; Filippini ; Domenico  ; De Leo
• 关键词：X-chromosome ; Population data ; Short tandem repeat
• 刊名：Forensic Science International: Genetics Supplement Series
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：3
• 期：1
• 页码：e327-e328
• 全文大小：100 K

文摘

Short tandem repeats (STRs) located on X chromosome are suitable in complex kinship cases when analysis performed using only autosomal loci does not provide informative results. In this work we evaluated the distribution of 12 X-STRs (DXS10103, DXS8378, DXS7132, DXS10134, DXS10074, DXS10101, DXS10135, DXS7423, DXS10146, DXS10079, HPRTB, DXS10148) using Investigator Argus X-12 PCR Amplification kit in a population sample of 207 unrelated healthy individuals (89 females and 118 males) living in North-East Italy. Allele frequencies and parameters of forensic interest were calculated for the twelve X-STRs. Some new microvariant and rare alleles in the loci DXS10148, DXS10101, DXS10079 have been detected. The Polymorphism Information Content (PIC) of the 12 X-STRs ranged from 0.642 (DXS8378) to 0.942 (DXS10135).