Deregulation of Adenosine Receptors in Psoriatic Epidermis: An Option for Therapeutic Treatment

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• 作者：Stefania Merighi¹ ; Pier Andrea Borea¹ ; ^bpa@unife.it ; Katia Varani¹ ; ^vrk@unife.it ; Stefania Gessi¹
• 刊名：Journal of Investigative Dermatology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：1
• 页码：11-13
• 全文大小：271 K
• 卷排序：137

文摘

Purinergic signaling is involved in psoriasis, a chronic skin disease characterized by increased epidermis cell growth. In particular, Andrés et al. focus on the keratinocyte biology modulated by adenosine receptors providing evidence that the A2B subtype plays a prominent role in the reduction of keratinocyte proliferation whereas A2A and A2B agonists have antiinflammatory effects independent of adenosine receptors. The authors report that psoriatic epidermis presents a deregulated adenosine receptor expression profile with reduced A2B and increased A2A.